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It considerably reduces cardiovascular events and improves inflammatory state and disease activity scores when used in conjunction with biologics for autoimmune diseases (such as RA and SLE) (274277)

The other adverse effect of the use of rhIGF-1 observed in GH receptor-deficient patients is hypoglycemia, due to low levels of IGFBP3 and increased level of free IGF-1 available for binding to insulin receptors [32]

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The more common cause of TP reduction is the decrease in ALB, which is the major protein component of serum TP, playing a role in maintaining plasma osmotic pressure and transporting nutrients (37)

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But theres a catch with that too (more on that later)